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In vitro activities of FBT432 and FBT374 in HEK293 cell-based assays.
| FBT432, IC50 (μM) | FBT374, IC50 (μM) | |
|---|---|---|
| IRE-reporter assays | ||
| FOXO1 | 0.069 × /÷ 1.79 | 0.073 × /÷ 1.20 |
| FOXO3 | >50 | 16.2 × /÷ 1.01 |
| FOXO4 | >50 | 1.63 E+01 |
| FOXA2 | >50 | >50 |
| Non-specific activities | ||
| pCMV-Rluc | >50 | >50 |
| Cell viability (LC50) | >50 | >50 |
IRE: insulin response element. Rluc: Renilla luciferase. Data are geometric mean x/÷ standard deviation.
