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. 2022 Sep 27;15(1):261–274. doi: 10.1016/j.jcmgh.2022.09.010

Figure 4.

Figure 4

Injection of polyI:C protects mice from alcohol-induced steatohepatitis. (A–D) EtOH-fed mice were injected intraperitoneally with PBS or polyI:C every other day after ethanol feeding (5 mg/kg). Mice were killed, and liver tissue was obtained at 6 hours after binge. The numbers of liver ILC1 and NK cells (A) and ILC1/NK cells ratio (B) were shown (n = 3/group). (C) Hepatic triglyceride content was measured in whole liver homogenate (n = 4/group). (D) H&E staining of liver section was performed (scale bars, 100 μm). (E) Plasma levels of ALT and AST were detected (n = 5/group). (F) The mRNA level of IL1β and IL6 in liver tissue was detected (n = 4/group). Two-tailed unpaired Student t tests were performed in A and B. Representative images are shown (n = 4/group). Two-way analysis of variance was performed in A. Two-tailed unpaired Student t test was performed in B, C, E, and F. ∗P < .05, ∗∗P < .01, ∗∗∗P < .001, ∗∗∗∗P <.0001.