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. 2022 Nov 7;13:1053330. doi: 10.3389/fmicb.2022.1053330

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Copyright © 2022 Zhou, Yong, Zhu, Yang and Fang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of exogenous D-ribose on central carbon metabolism. (A,B) Percent survival of SCH-R and clinical isolates by (A) bromopyruvate and (B) malonate dose and 1 MIC gentamicin plus 24 mM D-ribose. (C,D) PMF of SCH-R and clinical isolates by (C) bromopyruvate and (D) malonate dose with 24 mM D-ribose. (E,F) Intracellular NADH concentration of SCH-R and clinical isolates by (E) bromopyruvate and (F) malonate dose with 24 mM D-ribose. (G,H) QRT-PCR for expression of key central carbon metabolism genes in the presence of 24 mM D-ribose. Results are displayed as the mean ± SEM and three biological repeats are carried out. Significant differences are identified (*p < 0.05 and **p < 0.01).