GILT-R37A does not evoke an insulin signaling response
(A) RAT2 fibroblast insulin reporter cells were treated with 0.01 nM to 100 μM concentrations of insulin, IGF2, rhGILT-GAA, or rhGILT-R37A-GAA protein. Each data point is presented as mean (triplicate) ± SD. Results were normalized to untreated cells. (B) Glycemia and (C) and HbA1c blood levels in experimental mice prior to termination; group medians with interquartile ranges (dotted lines show normal ranges) (n = 9–13). NT = non-treated. Bu = Busulfex.