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. 2022 Nov 5;25(12):105513. doi: 10.1016/j.isci.2022.105513

Figure 1.

Figure 1

Concept of chorioretinal imaging with STOC-T

(A) In STOC-T, the retina is probed with complex spatiotemporal light fields according to a wide-field imaging scheme (Full-Field OCT). As a result, there is no loss of light intensity with applied defocus, as is the case with confocal detection in scanning OCT methods. However, there is still image blurring associated with defocus. This blur, however, can be removed by the numerical defocus correction provided by the signals obtained with high-speed full-field interferometric registration. This preserves high (5um) lateral resolution with significant imaging depth, covering the entire extent of the chorioretinal complex (800um).

(B) The complex spatiotemporal light fields guarantee the removal of the optical cross-talk effect created by scattered light in the sample. In STOC-T, scattered light that hits the camera pixels without recovering the original structure does not contribute to interference signals and thus to the volumetric reconstruction.