Table 3.
Screening performance characteristics of physiologic scoring systems in predicting the 30-day mortality of COVID-19 patients
| Variables | 4C Mortality | NEWS2 | qSOFA | PRIEST |
|---|---|---|---|---|
| Cut-off | ≥13 | ≥6 | ≥2 | ≥8 |
| Sensitivity | 68.75 (61.3 - 75.5) | 78.98 (72.2 – 84.7) | 85.80 (79.7 -90.6) | 87.50 (81.7 – 92.0) |
| Specificity | 79.19 (76.1 – 82.1) | 77.76 (74.6 -80.7) | 66.87 (63.3 – 70.2) | 71.05 (67.6 – 74.3) |
| PPV | 43.8 (39.7 - 48.1) | 45.7 (41.9 – 49.6) | 37.9 (35.2 – 40.8) | 41.6 (38.6 – 44.7) |
| NPV | 91.5 (89.6 – 93.1) | 94.0 (92.1 – 95.4) | 95.2 (93.2 – 96.6) | 96.0 (94.2– 97.3) |
| PLR | 3.30 (2.78 - 3.92) | 3.55 (3.04 – 4.15) | 2.59 (2.30 – 2.91) | 3.02 (2.67 – 3.43) |
| NLR | 0.39 (0.32 - 0.49) | 0.27 (0.20 - 0.36) | 0.21 (0.15 - 0.31) | 0.18 0.12 - 0.26) |
| AUC | 0.804 (0.776-0.829) | 0.843 (0.818-0.866) | 0.788 (0.760-0.814) | 0.846 (0.821-0.868) |
Data are presented with 95% confidence intervals. PPV: Positive predictive value; NPV: Negative predictive value; PLR: Positive Likelihood Ratio; NLR: Negative Likelihood Ratio; and AUC: Area Under the receiver operating characteristic Curve.