Table 2.
Codons under negative selection
| Amino acid change | Nucleotide mutation | HBoV1 presenting the mutation (n, %) | SLAC | FEL | REL | Consensus | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| dN-dS | p value | dN-dS | p value | dN-dS | Bayes Factor | ||||||
| A145A | A435G | 1 (0.6%) | − 11.328 | 0.333 | − 198.922 | 0.062 | − 3.215 | 0.000 | – | ||
| Q147Q | G441A | 59 (34.1%) | − 82.751 | 0.004 | − 640.969 | 0.003 | − 20.716 | 0.000 | – | – | |
| S150S | A450T | 4 (2.3%) | − 11.328 | 0.343 | − 208.514 | 0.093 | − 3.380 | 0.000 | – | ||
| G159G | A477G | 12 (6.9%) | − 22.655 | 0.112 | − 429.518 | 0.004 | − 16.433 | 0.000 | – | ||
| V184V | T552C | 18 (10.4%) | − 11.328 | 0.333 | − 103.078 | 0.099 | − 1.275 | 0.000 | – | ||
| Q196Q | G588A | 26 (15.0%) | − 46.951 | 0.046 | − 266.130 | 0.042 | − 19.535 | 0.000 | – | – | |
| T220T | A660C | 1 (0.6%) | − 11.328 | 0.333 | − 218.146 | 0.073 | − 3.532 | 0.000 | – | ||
| K258K | G774A | 16 (9.2%) | − 23.484 | 0.106 | − 126.544 | 0.067 | − 3.163 | 0.000 | – | ||
Codon positions have been calculated using the ST1 virus originally discovered in Sweden (with accession number DQ000495). All codons with a significant value are represented
SLAC Single-Likelihood Ancestor Counting, FEL Fixed Effects Likelihood, REL Random Effects Likelihood