Fig. 4.

Steady-state pharmacokinetic (PK) profiles of repeated dosing of ciprofloxacin, grepafloxacin and levofloxacin in plasma, epithelial lining fluid (ELF) and alveolar macrophages (AMs). Observations are shown as dots and model predictions as lines, where the predicted concentration in the pulmonary compartments are the mean of the six lung zones. Three different models were used to predict pulmonary PK; a general passive permeability-limited model (grey solid lines), a drug-specific permeability-limited model (green dashed lines) and a quantitative structure–property relationship (QSPR)-informed perfusion-limited model (purple dotted lines)