Fig. 5.
Impact of drug-specific parameters on A steady-state maximum concentration and B 24-h area under the curve (AUC) for plasma, epithelial lining fluid (ELF) and alveolar macrophages (AMs). The drug-specific parameter altered included tissue partitioning coefficient (Kptissue), the n-octanol-water lipophilicity index (logP) and plasma clearance (CL) and molecular weight (data not shown). The drugs with median parameter values were used as comparator drugs and the colour gradient indicate the log2 change in AUC (A) or Cmax(B) relative to the comparator