Table 2.
Reporting odds ratios and information components for antidepressants-related withdrawal syndrome by class of antidepressant and for each antidepressant
| Drug | No. cases | No. of non-cases | ROR | Lower 95% CI | Upper 95% CI | IC | Lower 95% CI | Upper 95% CI |
|---|---|---|---|---|---|---|---|---|
| Antidepressants | 31,846 | 600,050 | 14.26 | 14.08 | 14.45 | 3.34 | 3.32 | 3.35 |
| Tricyclics | 667 | 64,091 | 2.8 | 2.59 | 3.02 | 1.46 | 1.33 | 1.55 |
| SSRIs | 14,050 | 276,560 | 13.65 | 13.41 | 13.9 | 3.5 | 3.47 | 3.52 |
| Others | 17,659 | 279,014 | 17.01 | 16.73 | 17.29 | 3.75 | 3.73 | 3.77 |
| Tricyclics | ||||||||
| Amitriptyline | 261 | 30,406 | 2.31 | 2.04 | 2.61 | 1.19 | 0.99 | 1.34 |
| Clomipramine | 150 | 9539 | 4.23 | 3.6 | 4.97 | 2.05 | 1.78 | 2.25 |
| Imipramine | 84 | 5473 | 4.12 | 3.32 | 5.12 | 2.00 | 1.64 | 2.26 |
| Doxepin | 74 | 6333 | 3.14 | 2.5 | 3.95 | 1.62 | 1.23 | 1.9 |
| Nortriptyline | 69 | 7512 | 2.47 | 1.95 | 3.13 | 1.28 | 0.88 | 1.57 |
| Desipramine | 34 | 2450 | 3.73 | 2.66 | 5.23 | 1.83 | 1.26 | 2.24 |
| Lofepramine | 8 | 3314 | 0.65* | 0.32 | 1.3 | −0.59* | −1.8 | 0.21 |
| SSRIs | ||||||||
| Paroxetine | 10,074 | 60,069 | 45.07 | 44.08 | 46.08 | 5.11 | 5.08 | 5.13 |
| Sertraline | 1900 | 70,754 | 7.22 | 6.89 | 7.56 | 2.79 | 2.71 | 2.85 |
| Fluoxetine | 853 | 71,982 | 3.18 | 2.98 | 3.41 | 1.65 | 1.54 | 1.73 |
| Citalopram | 670 | 35,771 | 5.03 | 4.66 | 5.44 | 2.3 | 2.17 | 2.39 |
| Escitalopram | 590 | 32,499 | 4.88 | 4.5 | 5.29 | 2.25 | 2.11 | 2.35 |
| Fluvoxamine | 130 | 9771 | 3.58 | 3.01 | 4.25 | 1.81 | 1.52 | 2.02 |
| Other antidepressants | ||||||||
| Duloxetine | 8583 | 56,620 | 40.74 | 39.78 | 41.72 | 5.01 | 4.97 | 5.04 |
| Venlafaxine | 6203 | 57,065 | 29.21 | 28.43 | 30.01 | 4.62 | 4.58 | 4.65 |
| Desvenlafaxine | 1701 | 16,121 | 28.36 | 26.96 | 29.82 | 4.65 | 4.57 | 4.71 |
| Bupropion | 566 | 63,236 | 2.41 | 2.21 | 2.61 | 1.25 | 1.11 | 1.35 |
| Mirtazapine | 306 | 26,755 | 3.07 | 2.75 | 3.44 | 1.6 | 1.41 | 1.74 |
| Trazodone | 230 | 19,235 | 3.21 | 2.82 | 3.66 | 1.66 | 1.44 | 1.82 |
| Nefazodone | 126 | 8600 | 3.94 | 3.3 | 4.7 | 1.94 | 1.65 | 2.15 |
| Vortioxetine | 60 | 13,363 | 1.21* | 0.94 | 1.56 | 0.27* | −0.16 | 0.58 |
| Vilazodone | 55 | 4843 | 3.05 | 2.34 | 3.98 | 1.57 | 1.12 | 1.89 |
| Milnacipran | 40 | 4289 | 2.51 | 1.84 | 3.42 | 1.29 | 0.76 | 1.67 |
| Mianserin | 35 | 7173 | 1.31* | 0.94 | 1.83 | 0.38* | −0.18 | 0.78 |
| Reboxetine | 21 | 2184 | 2.58 | 1.68 | 3.97 | 1.31 | 0.58 | 1.82 |
| Hypericum perforatum | 17 | 2177 | 2.1 | 1.3 | 3.38 | 1.02 | 0.2 | 1.59 |
| Agomelatine | 12 | 3633 | 0.89* | 0.5 | 1.56 | −0.16* | −1.14 | 0.51 |
| Esketamine | 5 | 1270 | 1.06* | 0.44 | 2.55 | 0.07* | −1.49 | 1.05 |
CI confidence interval, IC information component, ROR reporting odds ratio, SSRIs selective serotonin reuptake inhibitors
*Not significant