Table 3.
Comparison between serious and non-serious reactions
| Serious reactions | Non-serious reactions | OR (95% CI) | p value | |
|---|---|---|---|---|
| Age, mean (SD), years | 43.51 (14.68) | 45.87 (14.57) | NA | < 2.2 × 10−16 |
| Adolescents/adults | 152/6168 | 51/4426 | 2.14 (1.55–3.01) | < 1.17 × 10−06 |
| Females/males (n) | 8223/3071 | 8434/2601 | 1.21 (1.14–1.29) | 5.2 × 10−10 |
| DDD (mean ± SD) | 0.88 (1.84) | 0.80 (1.8) | NA | 0.7971 |
| Duration of the treatment, mean (SD), months | 25.55 (36.88) | 17.91 (32.96) | NA | < 2.2 × 10−16 |
| Duration of withdrawal syndrome, mean (SD), days | 24.59 (129.43) | 6.55 (65.29) | NA | 9.53 × 10−3 |
| With mood stabilisers, n | 810 | 427 | 1.93 (1.71–2.18) | < 2.2 × 10−16 |
| With benzodiazepines, n | 1643 | 870 | 1.99 (1.83–2.18) | 2.2 × 10−16 |
| With other antidepressants, n | 1427 | 940 | 1.56 (1.43–1.70) | < 2.2 × 10−16 |
| With antipsychotics, n | 568 | 176 | 3.28 (2.76–3.92) | < 2.2 × 10−16 |
| With ≥ 2 comedications, n | 1066 | 4247 | 2.62 (2.33–2.94) | < 2.2 × 10−16 |
| With ≥ 3 comedications, n | 276 | 65 | 4.25 (3.23–5.67) | < 2.2 × 10−16 |
| With ≥ 4 comedications, n | 44 | 7 | 6.21 (2.77–16.34) | 1.23 × 10−07 |
CI confidence interval, DDD defined daily dose, OR odds ratio, NA not applicable, SD standard deviation