Antidepressants are associated with a disproportionate reporting of withdrawal syndrome, with reporting differences across individual antidepressants.

When discontinuing antidepressants, extra caution should be taken in people discontinuing paroxetine, duloxetine, venlafaxine and desvenlafaxine, which showed the strongest disproportionate reporting of withdrawal syndrome.

Extra attention should also be paid in men, adolescents and younger adults, persons using antidepressants with other psychotropic comedications, and those on treatment for longer than two years, as these subgroups may experience longer and more severe antidepressant-related withdrawal syndrome.