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. 2022 Nov 7;13:1051647. doi: 10.3389/fimmu.2022.1051647

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Copyright © 2022 Nguyen, Radwanska and Magez

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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scRNA-seq analysis reveals heterogeneity of Macrophages population during early and late stage of T. evansi infection. (A) Uniform Manifold Approximation Projection (UMAP) of Macrophages sub-populations and their portion across 3 time points (pie charts). MDM: Monocytes Derived Macrophages, EBIM: Erythroblast Island Macrophages, TRM: Tissue Resident Macrophages. (B) Log-normalized expression of classical markers for M1 (upper panel) and M2 (lower panel) macrophages on combined Macrophages from 3 time points. (C) Co-expression levels of Nos2/Arg1 genes on 42dpi single and 42dpi pool datasets derived Macrophages. (D) Interferon gamma response score (Top panel), TNF alpha signaling via NF-kB score (Middle panel), and Inflammation response score (Bottom panel) of Macrophages sub-populations during infection.