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. 2022 Nov 7;13:1051647. doi: 10.3389/fimmu.2022.1051647

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Copyright © 2022 Nguyen, Radwanska and Magez

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tissue resident macrophages show multi potential roles during chronic T. evansi infection. (A) UMAP showing macrophages sub-population (first panel) and log-normalized expression of genes expressed by Tissue resident macrophages (B) Changes in expression of genes related to iron retention during infection. (C) UMAP showing expression of Vcamp1 and Igf1 genes. (D) Average expression of gene markers used for HSPCs and Erythroid annotation. (E) UMAP projection of Macrophages, HSPCs, and Erythroid populations on combined total spleen cells dataset and their cell number alteration during infection. (F) Chord diagram of the inferred Itga4/Itgb1 – Vcam1 interaction among cell populations. (G) Log-normalized expression of genes involved in Hematopoiesis and Erythropoiesis on HSPCs and Erythroid populations.