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. 2022 Nov 4;13:1039765. doi: 10.3389/fimmu.2022.1039765

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Copyright © 2022 Hurler, Toonen, Kajdácsi, van Bree, Brandwijk, de Bruin, Lyons, Bergamaschi, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, Sinkovits, Cervenak, Würzner and Prohászka

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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C1-INH complex levels in healthy adult individuals. C1-INH complex concentrations were measured in 96 healthy adult individuals, using the new immunoassays. Distributions of C1s/C1-INH complex (A) and MASP-1/C1-INH complex concentrations (B) are shown in histograms. Concentrations in healthy adults were furthermore stratified according to gender (C: C1s/C1-INH complex, D: MASP-1/C1-INH complex) and age (E: C1s/C1-INH complex, F: MASP-1/C1-INH complex). No significant differences between males (n=50) and females (n=46) were observed when comparing the groups using Mann-Whitney test. ns, not significant; r, correlation coefficient.