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. 2022 Nov 8;66:101631. doi: 10.1016/j.molmet.2022.101631

Figure 2.

Figure 2

Body weight (BW), body composition, and plasma glucose levels in Gcg-Cre rats from the FSU colony. A, Male Gcg-Cre rats display similar growth curves and BWs after weaning, regardless of genotype. B, Female Homo Gcg-Cre rats display slightly but significantly higher BW compared to WT rats (∗P < 0.05, Homo vs. WT) and Het rats (@P < 0.05, Homo vs. Het). C, There is no significant effect of genotype on body fat percentages in female Gcg-Cre rats, whereas Het Gcg-Cre rats have more body fat compared to Homo Gcg-Cre rats (∗P < 0.05). D, Genotype does not impact lean mass in Gcg-Cre rats of either sex. E, Morning plasma glucose levels in male and female ad lib fed (Fed) and overnight food deprived (Dep) Gcg-Cre rats. Baseline (Fed) plasma glucose levels were lower in Homo Gcg-Cre rats compared to WT and Hets (P < 0.05 for each comparison). Plasma glucose levels fell in Dep WT and Het rats compared to baseline (∗P < 0.001 within each genotype). Conversely, glucose levels in Homo rats did not fall after overnight food deprivation.