TABLE 1.
Demographic and Clinical Characteristics Among Participants With ADNC Only Versus ADNC + LATE-NC
| Characteristic | All n = 1100 | ADNC n = 735 | ADNC and LATE-NC n = 365 | p value |
|---|---|---|---|---|
| Age at death, mean (SD) | 83.2 (8.8) | 82.5 (8.9) | 84.5 (8.5) | <0.001 |
| Months between last UDS visit and death, mean (SD) | 12.5 (9.3) | 12.3 (9.1) | 13.1 (9.8) | 0.195 |
| Years of education, mean (SD) | 15.9 (3.1) | 15.8 (3.2) | 16 (3.0) | 0.206 |
| Female, n (%) | 537 (48.8) | 346 (47.1) | 191 (52.3) | 0.101 |
| Nonwhite race, n (%) | 77 (7.0) | 48 (6.5) | 29 (8.0) | 0.725 |
| APOE ε4 carrier, n (%) | 530 (48.2) | 328 (44.6) | 202 (55.3) | 0.003 |
| Cognitive status at last UDS visit, n (%) | <0.001 | |||
| Normal cognition | 126 (11.5) | 112 (15.2) | 14 (3.8) | |
| Impaired, not MCI | 20 (1.8) | 16 (2.2) | 4 (1.1) | |
| MCI | 111 (10.1) | 94 (12.8) | 17 (4.7) | |
| Dementia | 843 (76.6) | 513 (69.8) | 330 (90.4) | |
| Primary clinical diagnosis, n (%) | <0.001 | |||
| Normal cognition | 126 (11.5) | 112 (15.2) | 14 (3.8) | |
| Alzheimer disease | 766 (69.6) | 465 (63.3) | 301 (82.5) | |
| Lewy body disease | 72 (6.6) | 56 (7.6) | 16 (4.4) | |
| Frontotemporal disorders* | 49 (4.5) | 37 (5.0) | 12 (3.3) | |
| Other | 84 (7.6) | 63 (8.6) | 21 (5.8) | |
| CDR sum of boxes, mean (SD) | 10.3 (6.8) | 9.3 (7.0) | 12.4 (5.7) | <0.001 |
| CDR global score, n (%) | <0.001 | |||
| None | 124 (11.3) | 110 (15) | 14 (4.2) | |
| Questionable | 166 (15.1) | 133 (18.1) | 31 (9.3) | |
| Mild | 156 (14.2) | 107 (14.6) | 47 (14.1) | |
| Moderate | 233 (21.2) | 136 (18.5) | 88 (26.4) | |
| Severe | 421 (38.3) | 249 (33.9) | 154 (46.1) |
*
Includes MSA, PSP, CBD, FTLD with motor neuron disease (e.g. ALS), and other FTLD.
Missing data: ADNC: Education (n=7), Race (n=2), APOE ε4 (n=72), Primary clinical diagnosis (n=2); ADNC + LATE: Education (n=3), Race (n=1), APOE ε4 (n=31), Primary clinical diagnosis (n=1).
Bold values indicate statistical significance at the p<0.05 level.