TABLE 2.
Co-neuropathologic Features Present at Autopsy Among Participants With ADNC Only Versus ADNC + LATE-NC
| All n = 1100 | ADNC n = 735 | ADNC and LATE-NC n = 365 | p value | |
|---|---|---|---|---|
| AD neuropathologic change, n (%) | <0.001 | |||
| Not AD | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| Low | 185 (16.8) | 149 (20.3) | 36 (9.9) | |
| Intermediate | 264 (24.0) | 202 (27.5) | 62 (17.0) | |
| High | 651 (59.2) | 384 (52.2) | 267 (73.2) | |
| Thal phase, n (%) | <0.001 | |||
| 0 | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| 1–2 | 116 (10.6) | 90 (12.2) | 26 (7.1) | |
| 3–4 | 400 (36.4) | 309 (42.0) | 91 (24.9) | |
| 5 | 584 (53.1) | 336 (45.7) | 248 (68.0) | |
| Braak stage, n (%) | <0.001 | |||
| 0 | 7 (0.6) | 5 (0.7) | 2 (0.6) | |
| I–II | 148 (13.5) | 124 (16.9) | 24 (6.6) | |
| III–IV | 229 (20.8) | 174 (23.7) | 55 (15.1) | |
| V–VI | 716 (65.1) | 432 (58.8) | 284 (77.8) | |
| Neuritic plaque density, n (%) | <0.001 | |||
| None | 117 (10.6) | 96 (13.1) | 21 (5.8) | |
| Sparse | 135 (12.3) | 104 (14.2) | 31 (8.5) | |
| Moderate | 233 (21.2) | 162 (22.0) | 71 (19.5) | |
| Frequent | 615 (55.9) | 373 (50.8) | 242 (66.3) | |
| LATE-NC stage, n (%) | <0.001 | |||
| 0 | 735 (66.8) | 735 (100.0) | 0 (0.0) | |
| 1 | 69 (6.3) | 0 (0.0) | 69 (18.9) | |
| 2 | 259 (23.6) | 0 (0.0) | 259 (71.0) | |
| 3 | 37 (3.4) | 0 (0.0) | 37 (10.1) | |
| Lewy Bodies, n (%) | <0.001 | |||
| No Lewy body pathology | 612 (55.6) | 445 (60.5) | 167 (45.8) | |
| Brainstem predominant | 45 (4.1) | 32 (4.4) | 13 (3.6) | |
| Limbic or amygdala predominant | 237 (21.6) | 133 (18.1) | 104 (28.5) | |
| Neocortical | 175 (15.9) | 109 (14.8) | 66 (18.1) | |
| Region unspecified | 29 (2.6) | 15 (2.0) | 14 (3.8) | |
| Hippocampal sclerosis, n (%) | 159 (14.5) | 34 (4.6) | 125 (34.3) | <0.001 |
| Vascular brain injury, n (%) | ||||
| Brain arteriolosclerosis (moderate/severe) | 543 (49.4) | 338 (46.0) | 205 (56.2) | <0.001 |
| Infarcts or lacunes | 169 (15.4) | 116 (15.8) | 53 (14.5) | 0.568 |
| Microinfarcts | 268 (24.4) | 170 (23.1) | 98 (26.9) | 0.339 |
| Hemorrhages and microbleeds | 66 (6.0) | 49 (6.7) | 17 (4.7) | 0.185 |
Missing data: ADNC: Lewy bodies (n = 1), Hippocampal sclerosis (n = 2), Brain arteriolosclerosis (n = 3), Infarcts or lacunes (n = 8), Microinfarcts (n = 4), Hemorrhages and microbleeds (n = 7); TDP-43 inclusions in amygdala (n = 138), in hippocampus (n = 0), in neocortex (n = 97); ADNC + LATE: Lewy bodies (n = 1), Hippocampal sclerosis (n = 2), Brain arteriolosclerosis (n = 7), Infarcts or lacunes (n = 2), Microinfarcts (n = 1), Hemorrhages and microbleeds (n = 1); TDP-43 inclusions in amygdala (n = 54), in hippocampus (n = 4), in neocortex (n = 31).
Bold values indicate statistical significance at the p<0.05 level.