TABLE 3.
Co-neuropathologic Features Present at Autopsy Among Participants With ADNC Only Versus ADNC + LATE-NC, Stratified by ADNC Score
| All n = 1100 | Low/intermediate ADNC |
p value | High ADNC |
p value | |||
|---|---|---|---|---|---|---|---|
| ADNC n = 351 | ADNC and LATE-NC n = 98 | ADNC n = 384 | ADNC and LATE-NC n = 267 | ||||
| AD neuropathologic change, n (%) | 0.310 | — | |||||
| Not AD | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||
| Low | 185 (16.8) | 149 (42.5) | 36 (36.7) | 0 (0.0) | 0 (0.0) | ||
| Intermediate | 264 (24.0) | 202 (57.6) | 62 (63.3) | 0 (0.0) | 0 (0.0) | ||
| High | 651 (59.2) | 0 (0.0) | 0 (0.0) | 384 (100.0) | 267 (100.0) | ||
| Thal phase, n (%) | 0.029 | ||||||
| 0 | 0 (0.0) | 0.005 | 0 (0.0) | 0 (0.0) | |||
| 1–2 | 116 (10.6) | 90 (25.6) | 26 (26.5) | 0 (0.0) | 0 (0.0) | ||
| 3–4 | 400 (36.4) | 222 (63.3) | 49 (50.0) | 87 (22.7) | 42 (15.7) | ||
| 5 | 584 (53.1) | 39 (11.1) | 23 (23.5) | 297 (77.3) | 225 (84.3) | ||
| Braak stage, n (%) | 0.233 | — | |||||
| 0 | 7 (0.6) | 5 (1.4) | 2 (2.0) | 0 (0.0) | 0 (0.0) | ||
| I–II | 148 (13.5) | 124 (35.3) | 24 (24.5) | 0 (0.0) | 0 (0.0) | ||
| III–IV | 229 (20.8) | 174 (49.6) | 55 (56.1) | 0 (0.0) | 0 (0.0) | ||
| V–VI | 716 (65.1) | 48 (13.7) | 17 (17.4) | 384 (100.0) | 267 (100.0) | ||
| Neuritic plaque density, n (%) | 0.483 | 0.620 | |||||
| None | 117 (10.6) | 96 (27.4) | 21 (21.4) | 0 (0.0) | 0 (0.0) | ||
| Sparse | 135 (12.3) | 104 (29.6) | 31 (31.6) | 0 (0.0) | 0 (0.0) | ||
| Moderate | 233 (21.2) | 107 (30.5) | 29 (29.6) | 55 (14.3) | 42 (15.7) | ||
| Frequent | 615 (55.9) | 44 (12.5) | 17 (17.4) | 329 (85.7) | 225 (84.3) | ||
| LATE-NC stage, n (%) | <0.001 | <0.001 | |||||
| 0 | 735 (66.8) | 351 (100.0) | 0 (0.0) | 384 (100.0) | 0 (0.0) | ||
| 1 | 69 (6.3) | 0 (0.0) | 19 (19.4) | 0 (0.0) | 50 (18.7) | ||
| 2 | 259 (23.6) | 0 (0.0) | 63 (64.3) | 0 (0.0) | 196 (73.4) | ||
| 3 | 37 (3.4) | 0 (0.0) | 16 (16.3) | 0 (0.0) | 21 (7.9) | ||
| Lewy Bodies, n (%) | 0.141 | 0.008 | |||||
| No Lewy body pathology | 612 (55.6) | 234 (66.7) | 58 (59.2) | 211 (55) | 109 (40.8) | ||
| Brainstem predominant | 45 (4.1) | 24 (6.8) | 10 (10.2) | 8 (2.1) | 3 (1.1) | ||
| Limbic or amygdala predominant | 237 (21.6) | 38 (10.8) | 12 (12.2) | 95 (24.7) | 92 (34.5) | ||
| Neocortical | 175 (15.9) | 52 (14.8) | 14 (14.3) | 57 (14.8) | 52 (19.5) | ||
| Region unspecified | 29 (2.6) | 3 (0.9) | 3 (3.1) | 12 (3.1) | 11 (4.1) | ||
| Hippocampal sclerosis, n (%) | 159 (14.5) | 16 (4.6) | 39 (39.8) | <0.001 | 18 (4.7) | 86 (32.2) | <0.001 |
| Vascular brain injury, n (%) | |||||||
| Brain arteriolosclerosis (moderate/severe) | 543 (49.4) | 145 (41.3) | 57 (58.2) | 0.002 | 193 (50.3) | 148 (55.4) | 0.032 |
| Infarcts or lacunes | 169 (15.4) | 66 (18.8) | 17 (17.4) | 0.912 | 50 (13) | 36 (13.5) | 0.871 |
| Microinfarcts | 268 (24.4) | 90 (25.6) | 32 (32.7) | 0.320 | 80 (20.8) | 66 (24.7) | 0.514 |
| Hemorrhages and microbleeds | 66 (6.0) | 21 (6.0) | 7 (7.1) | 0.583 | 28 (7.3) | 10 (3.8) | 0.157 |
Missing data, stratified: LOW/INTERMEDIATE ADNC, ADNC: Brain arteriolosclerosis (n = 2), Infarcts or lacunes (n = 5), Microinfarcts (n = 2), Hemorrhages and microbleeds (n = 5); TDP-43 inclusions in amygdala (n = 60), in hippocampus (n = 0), in neocortex (n = 58). ADNC + LATE: Lewy bodies (n = 1), Brain arteriolosclerosis (n = 2), Infarcts or lacunes (n = 1); TDP-43 inclusions in amygdala (n = 19), in hippocampus (n = 1), in neocortex (n = 7). HIGH ADNC, ADNC: Lewy bodies (n = 1), Hippocampal sclerosis (n = 2), Brain arteriolosclerosis (n = 1), Infarcts or lacunes (n = 3), Microinfarcts (n = 2), Hemorrhages and microbleeds (n = 2); TDP-43 inclusions in amygdala (n = 78), in hippocampus (n = 0), in neocortex (n = 39). ADNC + LATE: Hippocampal sclerosis (n = 2), Brain arteriolosclerosis (n = 5), Infarcts or lacunes (n = 1), Microinfarcts (n = 1), Hemorrhages and microbleeds (n = 1); TDP-43 inclusions in amygdala (n = 35), in hippocampus (n = 3), in neocortex (n = 24).
Bold values indicate statistical significance at the p<0.05 level.