TABLE 5.
Clinical Symptoms at Most Recent Visit Prior to Death Present Among Participants With ADNC Only Versus ADNC + LATE-NC, Stratified by ADNC Score
| All n = 1100 | Low/intermediate ADNC |
p value | High ADNC |
p value | |||
|---|---|---|---|---|---|---|---|
| ADNC n = 351 | ADNC and LATE-NC n = 98 | ADNC n = 384 | ADNC and LATE-NC n = 267 | ||||
| Cognitive symptoms, n (%) | |||||||
| Memory | 953 (86.6) | 227 (64.7) | 85 (86.7) | <0.001 | 376 (97.9) | 265 (99.3) | 0.472 |
| Executive function | 898 (81.6) | 187 (53.3) | 74 (75.5) | <0.001 | 374 (97.4) | 263 (98.5) | 0.415 |
| Language | 747 (67.9) | 145 (41.3) | 56 (57.1) | 0.001 | 320 (83.3) | 226 (84.6) | 0.554 |
| Visuospatial | 620 (56.4) | 106 (30.2) | 40 (40.8) | 0.006 | 276 (71.9) | 198 (74.2) | 0.402 |
| Attention | 621 (56.5) | 119 (33.9) | 45 (45.9) | 0.001 | 257 (66.9) | 200 (74.9) | 0.091 |
| Fluctuating cognition | 176 (16.0) | 47 (13.4) | 10 (10.2) | 0.518 | 74 (19.3) | 45 (16.9) | 0.576 |
| Behavioral symptoms, n (%) | |||||||
| Apathy | 508 (46.2) | 95 (27.1) | 41 (41.8) | 0.012 | 223 (58.1) | 149 (55.8) | 0.838 |
| Depressed mood | 328 (29.8) | 91 (25.9) | 29 (29.6) | 0.319 | 123 (32.0) | 85 (31.8) | 0.818 |
| Visual hallucinations | 157 (14.3) | 39 (11.1) | 9 (9.2) | 0.791 | 71 (18.5) | 38 (14.2) | 0.162 |
| Auditory hallucinations | 45 (4.1) | 12 (3.4) | 3 (3.1) | 0.113 | 22 (5.7) | 8 (3.0) | 0.203 |
| Delusions | 180 (16.4) | 26 (7.4) | 11 (11.2) | 0.453 | 84 (21.9) | 59 (22.1) | 0.881 |
| Disinhibition | 201 (18.3) | 29 (8.3) | 15 (15.3) | 0.006 | 92 (24.0) | 65 (24.3) | 0.749 |
| Irritability | 352 (32.0) | 70 (19.9) | 29 (29.6) | 0.068 | 157 (40.9) | 96 (36.0) | 0.404 |
| Agitation | 286 (26.0) | 32 (9.1) | 22 (22.5) | 0.001 | 138 (35.9) | 94 (35.2) | 0.539 |
| Personality change | 141 (12.8) | 23 (6.6) | 7 (7.1) | 0.006 | 70 (18.2) | 41 (15.4) | 0.525 |
| Motor symptoms, n (%) | |||||||
| Gait disorder | 478 (43.5) | 123 (35) | 35 (35.7) | 1.000 | 189 (49.2) | 131 (49.1) | 0.848 |
| Falls | 254 (23.1) | 77 (21.9) | 17 (17.4) | 0.104 | 101 (26.3) | 59 (22.1) | 0.326 |
| Tremors | 236 (21.5) | 68 (19.4) | 20 (20.4) | 0.069 | 89 (23.2) | 59 (22.1) | 0.540 |
| Slowness | 482 (43.8) | 127 (36.2) | 35 (35.7) | 0.772 | 187 (48.7) | 133 (49.8) | 0.498 |
Missing data, stratified: LOW/INTERMEDIATE ADNC, ADNC: Executive function (n = 4), Language (n = 2), Visuospatial (n = 16), Attention (n = 7), Fluctuating cognition (n = 52), Apathy (n = 3), Depressed mood (n = 1), Visual hallucinations (n = 5), Auditory hallucinations (n = 7), Delusions (n = 9), Disinhibition (n = 1), Irritability (n = 4), Agitation (n = 2), Personality change (n = 2), Gait disorder (n = 5), Falls (n = 4), Tremors (n = 3), Slowness (n = 4); ADNC + LATE: Executive function (n = 2), Language (n = 3), Visuospatial (n = 10), Attention (n = 7), Fluctuating cognition (n = 64), Apathy (n = 1), Depressed mood (n = 2), Visual hallucinations (n = 2), Auditory hallucinations (n = 6), Delusions (n = 3), Disinhibition (n = 3), Irritability (n = 2), Agitation (n = 2), Personality change (n = 5), Gait disorder (n = 1), Falls (n = 4), Tremors (n = 4), Slowness (n = 2); HIGH ADNC, ADNC: Memory (n = 2), Executive function (n = 2), Language (n = 3), Visuospatial (n = 20), Attention (n = 21), Fluctuating cognition (n = 26), Apathy (n = 6), Depressed mood (n = 15), Visual hallucinations (n = 22), Auditory hallucinations (n = 29), Delusions (n = 25), Disinhibition (n = 9), Irritability (n = 7), Agitation (n = 5), Personality change (n = 8), Gait disorder (n = 10), Falls (n = 14), Tremors (n = 21), Slowness (n = 15); ADNC + LATE: Memory (n = 0), Executive function (n = 2), Language (n = 4), Visuospatial (n = 18), Attention (n = 11), Fluctuating cognition (n = 15), Apathy (n = 4), Depressed mood (n = 8), Visual hallucinations (n = 23), Auditory hallucinations (n = 25), Delusions (n = 20), Disinhibition (n = 4), Irritability (n = 4), Agitation (n = 1), Personality change (n = 4), Gait disorder (n = 9), Falls (n = 7), Tremors (n = 10), Slowness (n = 6).
Bold values indicate statistical significance at the p<0.05 level.