Table II.
Selected down-stream activated Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways associated with the 13 most differentially expressed miRNAs between initial diagnostic MF patch and plaque skin lesions
| KEGG pathway | p-value | Regulated genes n | miRNAs involved n |
|---|---|---|---|
| TGF-beta signalling pathway | 0.0002 | 29 | 10 |
| FoxO signalling pathway | 0.0003 | 53 | 12 |
| mTOR signalling pathway | 0.006 | 27 | 10 |
| Pathways in cancer | 0,029 | 122 | 12 |
| PI3K-Akt signalling pathway | 0.043 | 97 | 12 |
| Transcriptional misregulation in cancer | 0.044 | 55 | 11 |
KEGG: Kyoto Encyclopedia of Genes and Genomes; TGF: transforming growth factor; FoxO: forkhead box O; mTOR: echanistic target of rapamycin; PI3K-Akt: phosphatidylinositol 3-kinase – serine/threonine kinase.