TABLE 3.

Neutralization of TNF-α in vivo caused reactivation in variant C of the Cornell model^a

Days of antibody treatment	MP6-XT22			Normal rat IgG
	Mouse no.	CFU in spleen	CFU in lung	Mouse no.	CFU in spleen	CFU in lung
48	1	0	0	4	0	0
	2	0	0	5	0	0
	3	0	320b	6	0	0
98	7	0	0	12	0	0
	8	0	0	13	0	0
	9	12,000c	6,000c	14	0	0
	10	12,000c	6,000c	15	0	0
	11	2,360	6,000c	16	0	0
126	17	480	0	21	0	0
	18	0	28	22	0	0
	19	1,204	0	23	0	0
	20	16	0	24	0	0

^aThe numbers of viable M. tuberculosis bacilli in spleen and lungs of individual animals were determined by plating organ homogenates. The limit of detection was 10 CFU/organ. 

^bBacteria with altered growth and staining properties. 

^cPlates were confluent at the time of counting, so the reported number of bacteria is approximate and likely is underestimated.