Figure 1. Study design and comparison of fresh vs. frozen profiling.
(A) Study design including specimens, analyses and validation approaches. (B) Quality-control parameters of a matched MBM specimen profiled with sc/snRNA-seq. (C,D) UMAP embedding with (C) cell type assignment and (D) profiling method. (E) Inferred copy number alterations (CNAs) from a matched MBM specimen processed with scRNA-seq (top) and snRNA-seq (bottom).