Table 3.
Summary statistics and results from mixed model analysis of primary and secondary outcomes
Descriptive statistics | Mixed model analysis | |||||
---|---|---|---|---|---|---|
Primary and secondary outcomes | Visit | gPM + (n = 168) | EUC (n = 189) | Difference in LS mean (95% CI) | p-value | Effect size |
Estimated mean (s.e.) | Estimated mean (s.e.) | |||||
HSCL-25 Depression | Baseline | 36.57 (0.67) | 35.15 (0.67) | |||
6-week | 29.95 (0.72) | 32.44 (0.69) | 3.92 (1.84–5.99) | 0.001 | 0.43 | |
3 months | 29.03 (0.73) | 31.28 (0.69) | 3.68 (1.54–5.81) | 0.001 | 0.40 | |
12 months | 28.26 (0.78) | 25.85 (0.73) | −0.98 (−3.23 to 1.26) | 0.39 | −0.11 | |
HSCL-25 Anxiety | Baseline | 24.82 (0.46) | 25.00 (0.46) | |||
6-week | 20.42 (0.49) | 21.95 (0.47) | 1.35 (−0.22 to 2.93) | 0.09 | 0.22 | |
3 months | 20.03 (0.50) | 19.64 (0.47) | −0.57 (−2.21 to 1.06) | 0.49 | −0.09 | |
12 months | 19.34 (0.54) | 17.85 (0.50) | −1.67 (−3.39 to 0.04) | 0.06 | −0.27 | |
WHODAS 2.0 | Baseline | 23.53 (0.47) | 23.92 (0.47) | |||
6-week | 14.70 (0.49) | 15.63 (0.51) | 0.87 (−1.4 to 2.22) | 0.53 | 0.17 | |
3 months | 15.73 (0.50) | 14.98 (0.51) | −1.14 (−2.96 to 0.69) | 0.22 | −0.23 | |
12 months | 15.16 (0.56) | 13.81 (0.53) | −1.74 (−3.67 to 0.19) | 0.08 | −0.35 | |
PCL-5 | Baseline | 25.98 (0.91) | 26.72 (0.90) | |||
6-week | 16.07 (0.98) | 17.54 (0.93) | 0.73 (−2.52 to 3.98) | 0.66 | 0.05 | |
3 months | 10.29 (0.99) | 10.32 (0.94) | 0.01 (−3.97 to 2.54) | 0.67 | 0.00 | |
12 months | 2.60 (1.07) | 3.29 (1.00) | −0.06 (−3.48 to 3.36) | 0.97 | 0.00 | |
PSYCHLOPS | Baseline | 16.48 (0.31) | 15.72 (0.31) | |||
6-week | 13.35 (0.33) | 13.68 (0.32) | 1.08 (0.18–1.99) | 0.02 | 0.28 | |
3 months | 13.49 (0.34) | 13.60 (0.32) | 0.87 (−0.11 to 1.84) | 0.08 | 0.22 | |
12 months | 12.45 (0.36) | 11.77 (0.34) | 0.07 (−0.95 to 1.10) | 0.89 | 0.02 | |
PG-13 | Baseline | 27.97 (0.85) | 29.19 (0.87) | |||
6-week | 26.83 (0.90) | 27.73 (0.91) | −0.32 (−3.06 to 2.43) | 0.82 | −0.03 | |
3 months | 20.48 (0.92) | 21.42 (0.91) | −0.28 (−3.20 to 2.63) | 0.85 | −0.03 | |
12 months | 19.71 (0.99) | 19.79 (0.99) | −1.15 (−4.26 to 1.96) | 0.47 | −0.12 | |
PQ-B | Baseline | 13.33 (0.15) | 13.41 (0.15) | |||
6-week | 14.84 (0.16) | 14.44 (0.16) | −0.53 (−1.10 to 0.04) | 0.07 | −0.18 | |
3 months | 15.07 (0.17) | 14.96 (0.16) | −0.24 (−0.82 to 0.33) | 0.41 | −0.08 | |
12 months | 15.88 (0.18) | 15.79 (0.17) | −0.19 (−0.81 to 0.43) | 0.55 | −0.07 | |
APQ: Involvement | Baseline | 34.96 (0.82) | 34.56 (0.82) | |||
6-week | 33.75 (0.88) | 32.95 (0.85) | −0.39 (−3.46 to 2.67) | 0.80 | −0.04 | |
3 months | 31.90 0.90) | 31.86 (0.85) | 0.37 (−2.898 to 3.62) | 0.83 | 0.04 | |
12 months | 34.41 0.90) | 37.26 (0.91) | 3.25 (−0.08 to 6.58) | 0.06 | 0.38 | |
APQ: Supervision | Baseline | 14.97 (0.34) | 14.81 (0.34) | |||
6-week | 12.91 (0.37) | 13.54 (0.35) | 0.78 (−0.46 to 2.02) | 0.21 | 0.16 | |
3 months | 12.42 (0.38) | 12.42 (0.36) | 0.16 (−1.188 to 1.50) | 0.82 | 0.03 | |
12 months | 13.34 (0.41) | 12.23 (0.38) | −0.95 (−2.35 to 4.64) | 0.19 | −0.20 | |
APQ: Positive parenting | Baseline | 24.08 (0.43) | 24.62 (0.42) | |||
6-week | 23.45 (0.46) | 23.59 (0.44) | −0.40 (−1.949 to 1.14) | 0.61 | 0.08 | |
3 months | 21.86 (0.47) | 22.26 (0.45) | −0.14 (−1.76 to 1.48) | 0.86 | −0.03 | |
12 months | 24.19 (0.51) | 22.73 (0.47) | −2.01 (−3.70 to −0.31) | 0.02 | −0.41 | |
APQ: Discipline | Baseline | 15.49 (0.32) | 14.74 (0.32) | |||
6-week | 13.73 (0.34) | 13.52 (0.33) | 0.54 (−0.70 to 1.79) | 0.39 | 0.14 | |
3 months | 13.00 (0.35) | 13.57 (0.33) | 1.33 (0.17–2.49) | 0.03 | 0.33 | |
12 months | 13.29 (0.38) | 12.36 (0.35) | −0.17 (−1.40 to 1.05) | 0.78 | −0.04 | |
APQ: Punishment | Baseline | 6.08 (0.15) | 6.34 (0.15) | |||
6-week | 5.49 (0.16) | 5.55 (0.16) | −0.09 (−0.71 to 0.31) | 0.44 | −0.03 | |
3 months | 5.41 (0.17) | 5.47 (0.16) | −0.27 (−0.79 to 0.31) | 0.31 | −0.10 | |
12 months | 5.54 (0.18) | 5.34 (0.17) | −0.46 (−1.01 to 0.13) | 0.10 | −0.17 | |
PSC: Total score | Baseline | 14.79 (0.49) | 16.22 (0.48) | |||
6-week | 13.01 (0.54) | 13.99 (0.52) | −0.46 (−2.09 to 1.19) | 0.59 | −0.06 | |
3 months | 12.43 (0.53) | 13.35 (0.53) | −0.52 (−2.23 to 1.20) | 0.56 | −0.08 | |
12 months | 16.84 (0.62) | 17.28 (0.56) | −1.00 (−2.87 to 0.87) | 0.30 | −0.14 | |
PSC: Attention problems | Baseline | 3.89 (0.16) | 4.45 (0.16) | |||
6-week | 3.42 (0.17) | 3.83 (0.17) | −0.22 (−0.77 to 0.34) | 0.44 | −0.10 | |
3 months | 3.14 (0.18) | 3.77 (0.17) | −0.23 (−0.82 to 0.37) | 0.46 | −0.10 | |
12 months | 2.05 (0.20) | 3.48 (0.17) | −0.35 (−1.00 to 0.30) | 0.30 | −0.16 | |
PSC: Internalising | Baseline | 3.22 (0.11) | 3.35 (0.11) | |||
6-week | 2.84 (0.12) | 2.97 (0.12) | 0.01 (−0.38 to 0.40) | 0.96 | 0.00 | |
3 months | 2.85 (0.12) | 3.01 (0.12) | 0.04 (−0.38 to 0.45) | 0.87 | 0.03 | |
12 months | 2.66 (0.14) | 2.63 (0.13) | −0.16 (−0.61 to 0.29) | 0.49 | −0.10 | |
PSC: Externalising | Baseline | 3.63 (0.11) | 3.64 (0.11) | |||
6-week | 3.30 (0.12) | 3.30 (0.12) | −0.01 (−0.43 to 0.41) | 0.96 | 0.00 | |
3 months | 3.20 (0.12) | 3.37 (0.12) | 0.17 (−0.25 to 0.59) | 0.43 | 0.11 | |
12 months | 3.04 (0.14) | 2.88 (0.13) | −0.17 (−0.62 to 0.28) | 0.46 | −0.11 |
EUC, Enhanced usual care; LS, Least Square; HSCL, Hopkins Symptom Checklist (depression subscale score range: 10–40; anxiety subscale score range: 15–60; higher scores indicate elevated anxiety or depression); PQ-B, Brief Prodromal Questionnaire; WHODAS 2.0, WHO Disability Assessment Schedule 2.0 (total score range: 0–48; higher scores indicate more severe impairment); PCL-5, Posttraumatic Stress Disorder Checklist (total score range: 0–80; higher scores indicate more severe PTSD severity); PSYCHLOPS, Psychological Outcomes Profiles (total score range: 0–20; higher scores indicate poorer outcome); PG-13, Prolonged Grief Disorder 13 (total score range: 11–57; higher scores indicate poorer outcome); PQ, Prodromal Questionnaire; (total score range: 0–64; higher scores indicate poorer outcome); APQ, Alabama Parenting Questionnaire (Parental Involvement subscale score range: 10–50; Positive Parent subscale score range (total score range : 6–30; higher scores indicate poorer outcome); Supervision subscale score range 10–50; Discipline subscale score range 6–30; Punishment subscale score range 3–15; higher scores indicate elevated parental involvement, positive parenting, supervision, discipline and punishment). Paediatric Symptom Checklist is child's self-report (PSC; Attention Problems subscale score range: 0–10; Internalising subscale score range: 0–10; Externalising subscale score range: 0–14). Effect size was calculated by the difference in least square means between intervention and EUC from mixed model divided by the pooled standard deviation.