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. 2022 Oct 25;4(6):fcac271. doi: 10.1093/braincomms/fcac271

Figure 2.

Figure 2

Manhattan-plot showing association results for ICV (n = 79 174) with 42.91 million sequence variants (SNPs, In-dels and SVs). Each dot represents the position of a tested marker for the association. The x-axis represents the chromosomal position of the tested marker (where 23 refers to chromosome X), and the y-axis represents the significance (−log10P) of the observed association. The horizontal dotted line represents P = 1.2 × 10−9 (0.05/42.9 × 106). Novel associations are highlighted with diamond shape, whereas bold filled dots represent associations of variants already reported in the scientific literature (Supplementary Table 1). The basic GWAS descriptive statistics calculated for ICV meta-analysis through LDSC61,62 are h2 = 0.0626 (0.0044 SE), lambda GC = 1.2818, mean Chi2 = 1.4252 and intercept = 1.0397 (0.0136 SE).