Table 2. The 12-month prevalence of substance-related problems based on screening instruments: extrapolation to the 18- to 64-year-old population.

Problematic use	Men			Women			Total *6			Extrapolation *7
	n	%	[95% CI]	n	%	[95% CI]	n	%	[95% CI]	N	[95% CI]
Tobacco *1	214	8.8	[7.5; 10.2]	225	6.8	[5.7; 8.1]	439	7.8	[6.9; 8.8]	4.0 M	[3.5; 4.5]
E-cigarettes *2	66	2.6	[1.9; 3.6]	40	1.2	[0.8; 2.0]	107	2.0	[1.5; 2.6]	1.0 M	[767; 1.3]
Heat-not-burn products *1	6	0.2	[0.1; 0.7]	12	0.2	[0.1; 0.5]	18	0.2	[0.1; 0.5]	102	[51; 256]
Alcohol *3	1 049	25.0	[23.1; 26.9]	655	10.1	[9.1; 11.2]	1 706	17.6	[16.5; 18.8]	9.0 M	[8.4; 9.6]
Cannabis *4	153	3.4	[2.8; 4.2]	111	1.6	[1.2; 2.2]	264	2.5	[2.1; 3.0]	1.3 M	[1.1; 1.5]
Cocaine *4	20	0.5	[0.3; 1.0]	14	0.2	[0.1; 0.4]	34	0.4	[0.2; 0.6]	205	[102; 307]
Amphetamine/methamphetamine *4	17	0.4	[0.2; 0.7]	14	0.4	[0.2; 0.8]	31	0.4	[0.2; 0.6]	205	[102; 307]
At least one drug *4	170	3.7	[3.0; 4.6]	27	2.0	[1.5; 2.5]	297	2.9	[2.4; 3.4]	1.5 M	[1.2. 1.7]
Medications *5	139	4.8	[3.8; 6.1]	272	6.5	[5.7; 7.4]	412	5.7	[5.0; 6.4]	2.9 M	[2.6; 3.3]

*¹ Based on the Fagerström Test for Nicotine Dependence

*² Based on the Penn State Electronic Cigarette Dependence Index

*³ Based on the Alcohol Use Disorder Identification Test

*⁴ Based on the Severity of Dependence Scale

*⁵ Based on the Short Questionnaire on Medication Use

*⁶ Includes men, women, and diverse

*⁷ Mean based on 51,139,451 individuals aged 18–64 years (as of 31 December 2020, German Federal Statistical Office)

n = Unweighted number; % = weighted prevalence; 95% CI = 95% confidence interval; N = extrapolation in thousands except where millions indicated; M, million