TABLE. Family Herpesviridae and neuroinfections.

	HSV-1	HSV-2	VZV	EBV	HCMV	HHV-6A	HHV-6B	HHV-7	HHV-8
Year of discovery	1920 1	1920 1	1952 17	1964 71	1956 26	1986 40	1988 41	1990 60	1994 80
Name	Herpes simplex virus 1	Herpes simplex virus 2	Varicella-zoster virus	Epstein-Barr virus	Human cytomegalovirus	Human herpesvirus-6A	Human herpesvirus-6B	Human herpesvirus-7	Human herpesvirus-8
Taxonomy ICTV (2021)	Human alphaherpesvirus 1	Human alphaherpesvirus 2	Human alphaherpesvirus 3	Human gammaherpesvirus 4	Human betaherpesvirus 5	Human betaherpesvirus 6A	Human betaherpesvirus 6B	Human betaherpesvirus 7	Human gammaherpesvirus 8
Discoverer(s)	Gruter 1	Gruter 1	Thomas H. Weller 17	Michael Anthony Epstein 71	Weller Smith and Rowe 26	Salahuddin 40	Yamanishi 41	Frenkel 60	Yuan Chang 80
Genome	152 kb 3	155 kb 4	125 kb 18	170 kb 70	236 kb 27	159 kb 43	162 kb 44	144 kb 61	140 kb 82
Latency	Neurons 5 , 7	Neurons 5 , 7	Neurons 20	Memory B cells 73	Renal epithelial cells and salivary glands 31	Monocytes, macrophage and glial cells ( 48 , 50	Salivary glands, monocytes, macrophages and glial cells 47 , 48 , 50	Unclear	B lymphocytes 83 , 84
Clinical manifestations	Skin lesions 5	Genital or anal blisters or ulcers 6	Varicella, herpes zoster 19 , 21	Infectious mononucleosis 72	Congenital viral infection 34	Asymptomatic 45 , 49 , 56	Exanthema subitum, present in infantile roseola 42 , 45 , 49 , 56	Exanthema subitum, fever without exanthema, febrile convulsions and status epilepticus 65	Kaposi’s sarcoma, primary effusion lymphoma and multicentric Castleman disease 81
Neurological manifestations	Encephalitis, meningitis, and meningoencephalitis 10 - 12	Encephalitis, meningitis, and meningoencephalitis 10 - 11	Post-herpetic neuralgia, meningoencefalitis, ischemic stroke, aneurysm and cerebral venous thrombosis 21 - 23	Meningitis, encephalitis, myelitis, psychoses and “Alice in Wonderland” syndrome 72 , 75 , 76	Encephalitis and neurodevelopmental deficits 35 , 36 - 38	Encephalitis and multiple sclerosis 49 - 51 , 56 , 58	Seizures, encephalitis, mesial temporal lobe epilepsy and multiple sclerosis 49 - 54	Seizures, encephalitis, meningoencephalitis, facial palsy, vestibular neuritis, severe headache, drowsiness, fatigue, photosensitivity, ataxia and coma 69	Under investigation
Research in progress	Alzheimer’s disease 14 - 16	Alzheimer’s disease 14 - 16	-	Multiple sclerosis 74 , 77 , 78	Schizophrenia 37 - 39	Multiple sclerosis 56 , 59	Epilepsy and multiple sclerosis 48 , 53 , 54 , 59	Epilepsy 66	_

EBV: Epstein-Barr virus; HCMV: human cytomegalovirus; HHV: human herpesvirus; HSV: herpes simplex virus; ICT: International Committee on Taxonomy of Viruses; VZV: varicella zoster virus.