Tabella A:

Algoritmo per identificare i pazienti ABSSSI non severa in Italia (Marcellusi et al. 2020 [18])

The following algorithm was implemented for all acute inpatient admissions with discharge dates between January 1st, 2006, and December 31th, 2014, in the Italian Hospital Information System (HIS). To define non-severe patients requiring observation over 12 hours, one of the following inclusion criteria had to have been met: All acuteinpatient admissions with discharge

AND a primary diagnosis as follows: ~“Cellulitis or abscess of the finger or toe” (ICD-9-CM 681.xx) ~“Other cellulitis or abscess” (ICD-9-CM 682.x) ~“Other local infection of the skin or subcutaneous tissue” (ICD-9-CM 686.xx) ~“Posttraumatic wound infection not elsewhere classified” (ICD-9-CM 958.3) ~“Other post-operative infection” (ICD-9-CM 998.59)

OR a diagnosis-related group (DRG) as follows: ~“Cellulitis, age >17 with complications” (DRG 277) ~“Cellulitis, age >17 without complications” (DRG 278) ~“Post-operative or post-traumatic infection” (DRG 418)

Exclusion criteria: Hospitalized patients aged < 17 years Hospitalizations with a length of stay < 1 day

Definition of a “non-severe” case: All selected admissions with a length of stay ≤ 3 days

AND a diagnosis-related group (DRG) not including the following: “Subtotal mastectomy for malignancy with CC” (DRG 259) “Extensive procedure unrelated to the principal diagnosis” (DRG 468) “Ungroupable” (DRG 470) “Prostatic procedure unrelated to the principal diagnosis” (DRG 476) “Non-extensive procedure unrelated to the principal diagnosis” (DRG 477) “Tracheostomy for face, mouth and neck diagnoses” (DRG 482) “Tracheostomy except for face, mouth and neck diagnoses” (DRG 483) “Extracorporeal membrane oxygenation or tracheostomy with mechanical ventilation ≥ 96 hours or a principal diagnosis unrelated to the face, mouth and neck, with a major procedure” (DRG 541) “Tracheostomy with mechanical ventilation ≥ 96 hours or a principal diagnosis unrelated to the face, mouth and neck, without a major procedure” (DRG 542)

Algorithm to identify ABSSSI patients For mapping between ICD9-ICD10 codes, the “ICD-9 to ICD-10 Code Search | ICD-10 Code Lookup & Crosswalk” tool was used, and the correspondences were double-checked.