Skip to main content
. Author manuscript; available in PMC: 2022 Nov 21.
Published in final edited form as: Cell Rep. 2022 Jul 26;40(4):111137. doi: 10.1016/j.celrep.2022.111137

Figure 6. Post-stroke ISP treatment leads to enhanced functional recovery in mice.

Figure 6.

(A) Experimental timeline.

(B) Representative MRI images at different coronal levels.

(C) At day 1 after stroke, before any treatment, the 2 groups of animals have similar infarct sizes and distributions. Post-stroke ISP treatment leads to enhanced general and fine locomotor functions as well as improved cognitive skills.

(D) General locomotor performance was measured by automated open field chambers for 1 h.

(E and F) Fine motor function was measured by the adhesive tape removal test (E) and cognitive function was measured by Barnes maze at 4 weeks after stroke (F).

*p < 0.05, **p < 0.01, ***p < 0.001, 2-way repeated-measures (RM) ANOVA for (D) and (E) and Student’s t test for (F). Each data point represents an individual mouse, data pooled from 2 independent cohorts.