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. Author manuscript; available in PMC: 2022 Nov 21.
Published in final edited form as: Cell Rep. 2022 Jul 26;40(4):111137. doi: 10.1016/j.celrep.2022.111137

Figure 7. Post-stroke ISP treatment starting at post-stroke day 7 also leads to enhanced behavioral functional recovery in mice.

Figure 7.

(A) Experimental timeline.

(B) Representative MRI images at different coronal levels.

(C) At day 1 after stroke, before any treatment, the 2 groups of animals have similar infarct sizes and distributions.

(D–F) Post-stroke ISP treatment leads to enhanced general locomotor function measured by automated open field chambers for 1 h (D), increased fine motor function measured by the adhesive tape removal test (E), and improved cognitive function measured by Barnes maze at 4 w after stroke (F).

*p < 0.05, **p < 0.01. Two-way RM ANOVA for (D) and (E) and Student’s t test for (F). Each data point represents an individual mouse; data from 1 cohort.