Table 3.
Factors associated with CD4+ T cells recovery in HIV-1-infected patients
| Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|
| OR (95% CI) | P | a0R (95% CI) | P | |
| Gender | ||||
| Male | 1.0 | 1.0 | ||
| Female | 3.024 (1.323, 6.911) | 0.009 | 0.972 (0.13, 7.28) | 0.978 |
| Age (years) | ||||
| ≤ 60 | 1.0 | 1.0 | ||
| > 60 | 4.505 (1.646, 12.324) | 0.003 | 3.888 (0.465, 32.519) | 0.210 |
| BMI (kg/m2) | 0.887 (0.742, 1.06) | 0.187 | ||
| Transmission category | ||||
| Heterosexual | 1.0 | |||
| Others | 0.988 (0.196, 4.99) | 0.988 | ||
| Initial HAART regimen | ||||
| TDF + 3TC + EFV | 1.0 | |||
| AZT/3TC + EFV | 2.291 (0.923, 5.685) | 0.074 | ||
| Others | 1.385 (0.461, 4.155) | 0.562 | ||
| Baseline CD4+ T cell Counts (cells/μL) | ||||
| ≥ 100 cells/μL | 1.0 | 1.0 | ||
| < 100 cells/μL | 3.636 (1.666, 7.939) | 0.001 | 7.051 (1.115, 44.592) | 0.038 |
| Baseline CD8+ T cell countsa | 1.024 (0.91, 1.152) | 0.697 | ||
| Baseline CD4/CD8 ratio | 0.11 (0.003, 3.497) | 0.211 | ||
| Baseline WBC(× 109/L)b | 0.94 (0.736, 1.201) | 0.619 | ||
| The relative expression of GSDMD mRNAc | 1.636 (1.016, 2.633) | 0.043 | 2.49 (0.779, 7.959) | 0.124 |
| The relative expression of Caspase-1 mRNA c | 1.66 (1.158, 2.379) | 0.006 | 2.803 (1.065, 7.377) | 0.037 |
| The expression of GSDMDd | 1.541 (0.578, 4.112) | 0.388 | ||
| The expression of Caspase-1e | 2.716 (1.019, 7.235) | 0.046 | 1.846 (0.291, 11.691) | 0.515 |
| The expression of IL-18 cytokinef | 3.883 (1.692, 8.907) | 0.001 | 10.131 (1.616, 63.505) | 0.013 |
| The expression of IL-1β cytokineg | 1.151 (0.846, 1.565) | 0.370 | ||
Per 1-year increase in duration
OR odds ratio; CI confidence interval; BMI body mass index; aOR adjust odds ratio
aPer 100 cells/μL increase
bPer 1 × 109 cells/μL increase
cPer 1 log increase
dPer 30 pg/mL increase
ePer 50 pg/mL increase
fPer 300 pg/mL increase
g Per 100 pg/mL increase