Table 2.
Comparison of baseline characteristics according to FIB-4 index
| Variables | FIB-4 < 2.67 (Low-intermediate risk of advanced liver fibrosis) N = 6011 |
FIB-4 ≥ 2.67 (High risk of advanced liver fibrosis) N = 76 |
P value |
|---|---|---|---|
| Age (year) | 47 (11-89) | 72 (41-88) | < 0.001† |
| Male (%) | 50.4 | 57.9 | 0.120‡ |
| Smoking (%) | 21.2 | 7.9 | 0.002‡ |
| Habitual drinking (%) | 12.7 | 25.7 | 0.002‡ |
| BMI (kg/m2) | 22.4 (10.6-61.1) | 22.4 (16.8-31.2) | 0.948† |
| Obesity (%) | 25.7 | 26.3 | 0.493‡ |
| Waist circumference (cm) | 80.0 (54.1-152.5) | 79.8 (57.5-112.5) | 0.229† |
| Large waist circumference (%) | 26.3 | 34.2 | 0.080‡ |
| Systolic blood pressure (mmHg) | 124 (77-244) | 138 (105-174) | < 0.001† |
| Diastolic blood pressure (mmHg) | 74 (34-140) | 78 (51-106) | 0.019† |
| Fasting plasma glucose (mg/dL) | 92 (57-295) | 104 (79-321) | < 0.001† |
| HbA1c (%) | 5.6 (4.4-14.6) | 5.7 (5.1-8.6) | 0.001† |
| Triglyceride (mg/dL) | 80 (16-1,454) | 87 (30-432) | 0.280† |
| HDL cholesterol (mg/dL) | 63 (11-158) | 38 (38-103) | 0.364† |
| LDL cholesterol (mg/dL) | 122 (25-335) | 121 (61-178) | 0.148† |
| Uric acid (mg/dL) | 5.2 (0.4-11.6) | 5.2 (2.5-8.4) | 0.627† |
| Albumin (g/dL) | 4.4 (3.4-5.3) | 4.3 (3.7-4.9) | 0.040† |
| AST (IU/L) | 20 (5-203) | 28 (16-233) | < 0.001† |
| ALT (IU/L) | 18 (3-561) | 20 (7-212) | 0.009† |
| GGT (mg/dL) | 22 (5-1,086) | 27 (10-313) | < 0.001† |
| Platelet counts (× 104/μL) | 25.0 (8.5-59.5) | 14.8 (2.9-28.6) | < 0.001† |
| Hemoglobin (g/dL) | 14.2 (7.0-19.7) | 14.0 (8.1-17.0) | 0.152† |
| White blood cell (/μL) | 5,400 (1,900-17,800) | 4,500 (1,100-13,900) | < 0.001† |
| Creatinine (mg/dL) | 0.76 (0.30-14.1) | 0.79 (0.50-1.30) | 0.010† |
| Hypertension (%) | 31.3 | 78.9 | < 0.001‡ |
| Diabetes mellitus (%) | 5.0 | 23.7 | < 0.001‡ |
| Dyslipidemia (%) | 45.1 | 52.6 | 0.115‡ |
| Hyperuricemia (%) | 11.5 | 9.1 | 0.352‡ |
Data are expressed as median (range), †Mann-Whitney U-test, ‡Chi-squared test. ALT Alanine aminotransferase, AST Aspartate aminotransferase, BMI Body mass index, Fib-4 Fibrosis-4, GGT Gamma-glutamyl transpeptidase, HbA1c Hemoglobin A1c, HDL High-density lipoprotein, LDL Low-density lipoprotein