Table 2.

The Association of previously reported cluster headache loci in the current sample

Chr	Gene	Index SNP	Risk allele	Cona	OR [95%CI]	P1b	P2c	Ref No
1	near RP11-815M8.1	rs11579212	C	2	0.97 [0.78–1.2]	0.30	0.09	6
1	LINC01705/DUSP10	rs6687758	G	1	1.07 [0.94–1.23]	0.23	1.58 × 10–3	7
1	LINC01705/DUSP10	rs12121134	T	2	0.61 [0.22–1.69]	0.21	5.23 × 10–3	7
1	LINC01705	rs545037820	G	3	0.75 [0.50–1.12]	0.02
1	near LINC01705	rs2034485	T	3	1.31 [1.16–1.49]	1.16 × 10–6
1	DUSP10	rs145531779	C	3	1.43 [1.11–1.83]	0.02
2	MERTK	rs4519530	C	2	1.50 [1.32–1.72]	4.69 × 10–12	9.30 × 10–27	7
2	near MERTK	rs6541998	C	2	1.43 [1.25–1.63]	1.86 × 10–8	6.23 × 10–15	6
2	MERTK	rs10188640 rs10188642	A	3	1.52 [1.33–1.73]	8.58 × 10–13
2	near LINC01877/SATB2	rs4675692 rs113658130	G C	NA				7
2	LINC01877	rs13394614	G	3	1.34 [1.18–1.52]	5.42 × 10–7
2	STAB2	rs13028839	A	3	0.63 [0.52–0.78]	2.81 × 10–8
3	MME	rs147564881	C	NA				5
3	MME	rs56208271	A	3	1.61 [1.17–2.22]	4.56 × 10–3
3	near MME	rs143162143	C	3	2.29 [1.56–3.36]	1.15 × 10–4
4	CLOCK	rs12649507	G	2	0.88 [0.78–1.01]	0.07	1.02 × 10–3	21
4	CLOCK	rs369023808	G	3	1.19 [0.76–1.88]	0.04
4	near CLOCK	rs34945396	C	3	0.78 [0.66–0.92]	5.09 × 10–3
4	ADH4	rs1126671	T	1	1.72 [0.60–4.93]	0.04	1.46 × 10–3	20
4	ADH4	rs56314548	C	3	0.77 [0.51–1.17]	0.58
6	HCRTR2	rs3800539	A	2	1.13 [0.99–1.29]	0.14	0.13	26
6	HCRTR2	rs10498801	A	2	0.88 [0.75–1.02]	0.03	0.34	26
6	HCRTR2	rs2653349	A	2	0.77 [0.57–1.03]	0.49	0.10	23, 24
6	HCRTR2	rs3122156	G	NA				25
6	HCRTR2	rs78769350	G	3	0.69 [0.46–1.06]	0.03
6	near UFL1/FHL5	rs2499799	T	2	1.08 [0.85–1.36]	0.74	4.00 × 10–3	6
6	FHL5	rs11153082	G	2	1.19 [1.04–1.35]	1.99 × 10–4	7.54 × 10–11	7
6	FHL5	rs9386670	A	2	1.17 [1.02–1.34]	9.72 × 10–4	1.09 × 10–9	7
6	UFL1	rs2255552	G	3	1.18 [1.04–1.35]	1.83 × 10–4
6	FHL5	rs57425973	A	3	1.2 [1.05–1.37]	6.21 × 10–5
7	ADCYAP1R1	rs12668955	A	1	1.07 [0.96–1.19]	0.22	1.7 × 10–4	5
7	ADCYAP1R1	rs201504906 rs200124908	C	3	1.72 [1.31–2.26]	1.01 × 10–5
12	CRY1	rs8192440	A	1	0.96 [0.66–1.41]	0.42	0.09438	22

Abbreviations: Chr Chromosome, SNP Single nucleotide polymorphism, Con Condition, OR Odds ratio, CI Confidence interval, Risk allele, allele with higher frequency in cases compared to controls, NA Not available

^aCondition: 1. Information obtained from real genotyping data. 2. Information derived from imputation data. 3. Most significant SNP within or near the same gene in the imputation data

^bThe p values of Cochran-Armitage Trend Test

^cThe p values of meta-analysis of the previous studies and the current study