Table 3.

Lead SNPs of GWAS significant loci in the combined analysis for patients with cluster headache in Taiwan

SNP	Chr	Position	Gene	Minor allele	Stage	MAF(Case, Control)	OR	95% CI	P valuea	eQTL mapped genesc
rs1556780	1	223,755,834	CAPN2	G	1	(0.354, 0.253)	1.637	1.390‒1.927	2.34 × 10–9	CAPN2
					2	(0.344, 0.253)	1.540	1.316‒1.801	5.31 × 10–8
					Com	(0.329, 0.253)	1.586	1.416‒1.775	7.61 × 10–16
rs10188640	2	111,983,520	MERTK	A	1	(0.345, 0.257)	1.522	1.297‒1.787	2.17 × 10–7	AC012442.5, FBLN7, MERTK, RGPD8, TMEM87B, TTL, ZC3H8
					2	(0.343, 0.260)	1.481	1.266 ‒1.733	8.05 × 10–7
					Com	(0.349, 0.258)	1.501	1.342‒1.679	1.25 × 10–12
rs13028839	2	199,370,629	SATB2	A	1	(0.096, 0.154)	0.577	0.447–0.746	2.02 × 10–5	C2orf69, SATB2, AC019330.1
					2	(0.099, 0.149)	0.639	0.493–0.829	3.46 × 10–4
					Com	(0.102, 0.151)	0.634	0.518‒0.778	2.81 × 10–8

Abbreviations: SNP Single nucleotide polymorphism, Chr Chromosome, OR Odds ratio, CI Confidence interval, MAF Minor allele frequency

^aThe p values of Cochran-Armitage Trend Test The eQTL mapping was done with GTEx v.8