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. 2022 Nov 17;17:5391–5411. doi: 10.2147/IJN.S373282

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© 2022 Kong et al.

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Cellular internalization of ICG@SANPs-cRGD nanoparticles and mechanism of PTT and PDT in vitro. (A) Cellular uptake of ICG@SANPs, ICG@SANPs-cRGD in 4T1 cells. (B) The temperature changes of five different concentrations of ICG@SANPs-cRGD nanoparticles under near-infrared light irradiation with power density of 0.8w/cm2 and wavelength of 808nm. (C) The temperature changes of the same concentrations of ICG@SANPs-cRGD(10μg/mL) under different power densities of NIR (0.4w, 0.8w and 1.2w) with a wavelength of 808nm. (D) Representative pictures of ROS production in 4T1 cells after different treatments (scale bar = 100μm). (E) Quantitative fluorescence area ratio of ROS generation in 4T1 cells after different treatments. (Data are expressed as means ± SD (n = 3). Statistical significances were calculated via ANOVA, *p < 0.05, ****p < 0.0001).