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Activity of 24b and 25b against mutant HIV-1 strains
| Compds | EC50 (nM)a |
|||||
|---|---|---|---|---|---|---|
| L100I | K103N | Y181C | Y188L | E138K | F227L+V106A | |
| 24b | <3.62 | <3.62 | 8.49±0.48 | 8.15±0.64 | 9.40±2.72 | 9.28±1.60 |
| 25b | 5.55±1.44 | 7.36±1.12 | 26.3±7.21 | 35.7±1.28 | 29.7±0.48 | 32.8±0.00 |
| ETR | 6.08±1.55 | 3.33±0.69 | 14.5±8.22 | 20.4±8.64 | 9.76±6.90 | 19.7±7.30 |
EC50: concentration of compound required to achieve 50% protection of MT-4 cell cultures against HIV-1-induced cytopathic effect, as determined by the MTT method.
