Table 7.

Human Microsomal Stability of 24b and 25b.

Compound	Human Liver Microsome
	R2	T1/2 (min)	CLint(mic) (μL/min/mg)	CLint(liver) (mL/min/kg)	Remaining (T=60min)
24b	0.9412	80.1	17.3	15.6	55.8%
25b	0.9322	32.7	42.4	38.2	23.8%
K-5a2	0.9973	2.4	577.3	519.6	0.8%
25a	0.992	1.6	847.3	762.5	0.2%
Propafenone	0.9846	5.2	265.9	239.3	0.1%

R² is the correlation coefficient of the linear regression for the determination of kinetic constant

CL_int(mic) = 0.693/half-life/mg microsome protein per mL

CL_{int (liver)} = CL_{int (mic)}*mg microsomal protein/g liver weight*g liver weight/kg body weight

Liver weight: 20 g/kg for human.