TABLE 2.
Univariable and multivariable analyses for overall mortality and cardiac death in the contemporary cohort.
| Parameters | Univariable analysis |
Multivariable analysis (OM) |
Multivariable analysis (CD) |
|||
| HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age at diagnosis, for every year increase | 1.001 (0.96–1.03) | 0.953 | ||||
| Male sex | 0.49 (0.25–0.95) | 0.035 | 0.62 (0.29–1.34) | 0.08 | 0.78 (0.26–2.30) | 0.66 |
| Scintigraphy vs. biopsy | 0.23 (0.12–0.46) | <0.001 | ||||
| ATTR vs. AL | 0.39 (0.20–0.73) | 0.004 | 0.42 (0.18–0.93) | 0.038 | 0.39 (0.15–0.96) | 0.042 |
| History of AF | 0.76 (0.41–1.42) | 0.394 | ||||
| Syncope | 2.44 (0.87–5.75) | 0.126 | ||||
| Hypertension | 1.08 (0.56–2.07) | 0.812 | ||||
| SBP, mmHg | 0.98 (0.96–1.007) | 0.173 | ||||
| Carpal tunnel | 0.54 (0.27–1.07) | 0.151 | ||||
| NYHA ≥ 3 | 1.76 (0.94–3.29) | 0.110 | ||||
| eGFR < 60 ml/min | 1.15 (0.61–2.18) | 0.655 | ||||
| eGFR, ml/min | 0.98 (0.97–1.001) | 0.07 | 0.98 (0.97–0.99) | 0.033 | 0.96 (0.94–0.98) | 0.041 |
| Low QRS voltages | 1.81 (0.95–3.45) | 0.123 | ||||
| BBs | 0.58 (0.30–1.11) | 0.104 | ||||
| ACEi/ARBs | 0.24 (0.12–0.48) | <0.001 | 0.24 (0.11–0.50) | <0.001 | 0.25 (0.09–0.69) | 0.007 |
| IVS, per every mm increase | 1.006 (0.94–1.07) | 0.866 | ||||
| LVEF, per every% increase | 1.004 (0.98–1.02) | 0.748 | ||||
| LVEF < 50% | 1.02 (0.52–1.99) | 0.943 | ||||
| E/E’, for every point increase | 0.99 (0.96–1.03) | 0.903 | ||||
| RFP | 0.47 (0.21–1.05) | 0.112 | ||||
| LA diameter, mm | 0.99 (0.96–1.02) | 0.858 | ||||
| RV dysfunction | 0.89 (0.46–1.73) | 0.741 | ||||
| Biventricular dysfunction | 0.69 (0.31–1.52) | 0.360 | ||||
| Moderate-severe MR | 1.37 (0.61–3.04) | 0.438 | ||||
| Aortic Stenosis | 1.41 (0.68–2.92) | 0.355 | ||||
| Pericardial effusion | 0.99 (0.50–1.93) | 0.979 | ||||
ACEi, Angiotensin-converting enzyme inhibitor; AF, Atrial Fibrillation; AL, Amyloid light chain; ARBs, Angiotensin II Receptor Blockers; ATTR, Transthyretin Amyloidosis; BBs, Beta Blockers; CD, Cardiac Death; eGFR, estimated Glomerular Filtration Rate; IVS, Interventricular septum; LA, Left Atrium; LVEF, Left Ventricular Ejection Fraction; LVH, Left Ventricular Hypertrophy; MR, Mitral regurgitation; NYHA, New York Heart Association; OM, Overall Mortality; RFP, Restrictive Filling Pattern; RV, Right Ventricle, SBP, Systolic Blood Pressure. Bold identifies parameters with p-value <0.05.