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. 2022 Sep 7;21(23):2484–2498. doi: 10.1080/15384101.2022.2103339

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Figure 2. — Downregulation of circPLOD2 inhibited proliferation, migration and invasion of colon cancer cells in vitro. (A) Transfection efficiency of two downregulation plasmids of circPLOD2 (sh-circ#1 and sh-circ#2) in HCT-116 and SW620 cells. (B and C) The cell viability and colony formation ability of HCT-116 and SW620 after different transfection were detected by CCK-8 assay and colony formation assay. (D and E) The cell migration and invasion were determined by transwell assays after knockdown of circPLOD2 in colon cancer cells. N = 3, all data were represented as mean ± SD. ***p < 0.001 vs. the control group (sh-nc).