Table 3.
Independent influencing factors of serum Ln(TMAO) by multivariate linear regression analysis in HD patientsa.
| Variables | First step |
Last step |
||
|---|---|---|---|---|
| B | p Value | B | p Value | |
| Constant | 0.771 | 0.224 | 1.041 | <0.001 |
| Dialysis vintage (months) | 0.003 | 0.002 | 0.003 | 0.001 |
| Diabetic mellitus (no = 0, yes = 1) | 0.285 | 0.005 | 0.309 | 0.002 |
| Serum urea (mmol/L) | 0.017 | 0.047 | 0.019 | 0.018 |
| Serum triglycerides (mmol/L) | 0.027 | 0.414 | Excluded | |
| Serum HDL-C (mmol/L) | –0.139 | 0.355 | Excluded | |
| Serum usCRP(mg/L) | 0.001 | 0.801 | Excluded | |
| Serum albumin (g/L) | 0.010 | 0.485 | Excluded | |
Ln(TMAO): the natural logarithm of trimethylamine-N-oxide; HD: hemodialysis; HDL-C: high-density lipoprotein cholesterol; usCRP: ultrasensitive C-reactive protein; B: partial regression coefficient.
a
All factors correlated or having the tendency correlated to serum Ln(TMAO) in Table 2, including dialysis vintage, diabetic mellitus, serum urea, triglycerides, HDL-C, usCRP, and serum albumin, were included in the multivariate linear regression model, using backward conditional methods for analysis.