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Overview of metabolic pathways that generate selected epigenome-modifying metabolites: methionine, S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), a-ketoglutarate (aKG), acetyl CoA, and NAD+. The enzymatic reactions and epigenomic modifications of these metabolites are summarized in Table 1 . Complex I of OXPHOS oxidizes NADH to NAD+. Acetyl CoA and aKG are metabolites of the TCA cycle. Methionine, SAM and SAH are critical components of the methionine cycle.
