Table 1.

Summary of selected metabolites, enzymatic interactions, and related epigenomic modification upon increase of the metabolite.

Metabolite	Enzymatic Interaction	Epigenomic modification
Methionine	Substrate for MAT, required for SAM production	Promotes DNA methylation
SAM	Substrate for DNMTs; activates activity	Promotes DNA methylation
SAH	Substrate for DNMTs; inhibits activity	Inhibits DNA methylation
α-ketoglutarate	Co-factor for TET and JMJD demethylases	Promotes DNA demethylation
Acetyl CoA	Substrate for HATs	Promotes histone acetylation
NAD+	Co-factor for sirtuins	Promotes histone deacetylation