TABLE 3.
Relationship between TMB and core genes
| N | Mean | 95%CI | p | |
|---|---|---|---|---|
| TP53 | ||||
| + | 163 | 5.1775 | 4.6550–5.7038 | 0.003 |
| − | 177 | 5.3329 | 4.4239–6.2437 | |
| ATM | ||||
| + | 11 | 10.1909 | 5.8400–14.8874 | 0.006 |
| − | 329 | 5.0935 | 4.5462–5.6248 | |
| PTEN | ||||
| + | 7 | 6.2557 | 3.7528–8.6342 | 0.168 |
| − | 333 | 5.2375 | 4.6827–5.7790 | |
| BRCA1 | ||||
| + | 8 | 7.7738 | 4.3800–11.6352 | 0.08 |
| − | 332 | 5.1987 | 4.6397–5.7482 | |
| HRAS | ||||
| + | 2 | 11.8250 | 8.7600–14.8900 | 0.054 |
| − | 338 | 5.2196 | 4.6696–5.7453 | |
| KRAS | ||||
| + | 25 | 7.3920 | 4.8762–10.1858 | 0.119 |
| − | 315 | 5.0891 | 4.5425–5.6402 | |
| PIK3CA | ||||
| + | 14 | 9.1800 | 5.5717–13.9133 | 0.008 |
| − | 326 | 5.0900 | 4.5554–5.6064 | |
| MYC | ||||
| + | 1 | 4.3800 | 4.3800–4.3800 | 0.865 |
| − | 339 | 5.2610 | 4.7306–5.8124 | |
| CDKN2A | ||||
| + | 16 | 7.6625 | 5.8387–9.3706 | 0.002 |
| − | 324 | 5.1397 | 4.5742–5.6958 | |
| CTNNB1 | ||||
| + | 29 | 6.4021 | 4.9457–7.9788 | 0.005 |
| − | 311 | 5.1518 | 4.5875–5.7167 | |
| MDM2 | ||||
| + | 4 | 10.2900 | 3.500–25.4000 | 0.130 |
| − | 336 | 5.1985 | 4.6432–5.7111 | |
| EGFR | ||||
| + | 216 | 4.3901 | 3.8777–4.8967 | 0.014 |
| − | 124 | 6.7710 | 5.6243–8.0017 | |
| ERBB2 | ||||
| + | 8 | 4.5998 | 2.6300–5.8167 | 0.901 |
| − | 332 | 5.2743 | 4.7019–5.8167 | |