Figure 1.

Integrated multiomic approach for exceptional health and life span. Multidimensional approaches to systems understanding of exceptional life span. Given the multifaceted nature of the healthy aging process, multidimensional approaches are required for the systems understanding of the healthy aging process to identify protective molecular factors and biological pathways governing exceptional life span from blood, cells, and tissues of human and nonhuman species. The various molecular layers encompassing genomic, epigenomic, transcriptomic, proteomic, metabolomic, and phenomic data, derived from high-throughput omics technologies are essential for an in-depth analysis by novel integrative approaches across species to identify protective molecular factors and biological pathways that influence exceptional health and life span.