Table 1.
Summary of EL Projects
| Study | Research Resources | Planned Analyses | Integration With Other Studies |
|---|---|---|---|
| Long-Life Family Study (LLFS) | |||
| Long-lived families | WGS | Linkage analyses to identify rare variants | LC, LG, and ILO |
| Methylomics | Integrated multiomic analyses | ||
| Transcriptomics (longitudinal) | Identification of mechanistic pathway(s) | ||
| Proteomics | |||
| Metabolomics (longitudinal) | |||
| Known serum biomarkers | |||
| Phenotypic data + cognitive functions | |||
| Longevity Consortium (LC) | |||
| Human centenarians | Metabolomics | Integrated analysis for longevity omics profiles | LLFS, ILO, and LG |
| Long-lived individuals (MrOS, SOF, CHS) | Proteomics | Identification of mechanistic pathway(s) | |
| Chemoinformatics | Druggability of longevity pathways | ||
| Phenotypic data + cognitive functions | |||
| Cell lines of birds, rodents, and primates | Metabolomics | Identification of human orthologs | |
| Slow-aging mice—plasma and tissues | Proteomics | ||
| Longevity Genomics (LG) | |||
| Publically available data | Identification of LAV and LAG | LC, LLFS, and ILO | |
| PrediXcan/MetaXcan | Identification of eQTLs | ||
| Mendelian randomization | |||
| DrugTarget identification | |||
| Chemoinformatics | Validation of potential targets | ||
| In vitro models/iPSCs/organoids | |||
| Integrative Longevity Omics (ILO) | |||
| Centenarians/controls | Transcriptomics | Integrated omic analyses | LLFS, LC, and LG |
| Methylomics | Identification of mechanistic pathway(s) | ||
| Proteomics | |||
| Metabolomics | |||
| Microbiomics | |||
| iPSC—centenarians | |||
| Nonhuman species | Transcriptomics | Human orthologs for genes/proteins | |
| ~100 species of mammal | Proteomics | Life-span-related mechanisms | |
| - multiple tissues/cell lines | Metabolomics | ||
| eg, primates, birds, rodents, bowhead whale | WGS |
Notes: eQTL = expression quantitative trait locus; iPSC = induced pluripotent stem cell; LAG = longevity-associated gene; LAV = longevity-associated variant; MrOS = Osteoporotic Fractures in Men; SOF = Study of Osteoporotic Fractures; WGS = whole-genome sequencing.