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. 2022 Nov 2;4(6):fcac282. doi: 10.1093/braincomms/fcac282

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Higher amyloid levels and faster amyloid deposition in progressors versus non-progressors. (A) Spaghetti plots of the linear mixed effect model-fitted amyloid SUVR levels show higher mean cortical and subcortical amyloid SUVR levels in progressors compared with non-progressors. Accumulation rates for mean cortical and subcortical amyloid levels did not differ significantly between groups. (B) Mean model-fitted amyloid values are shown in each of the 68 cortical regions from the Desikan–Killiany atlas. (C) Visualized statistically significant (false discovery rate-corrected P < 0.05) regions for a progression group × time interaction. (D) Compared with non-progressors, progressors show steeper slopes of amyloid accumulation in the right inferior temporal gyrus but not in the caudate nucleus as example regions.