Table 1.

Hydrodynamic diameter, polydispersity index (PDI), radius of main peak and relative intensity of main peak of untreated and stressed samples of Comirnaty vaccine determined by DLS.

Sample	Hydrodynamic radius [nm]	PDI	Radius of main peak [nm]	Relative intensity of main peak [%]
Untreated	66 ± 9	Multimodal	36 ± 2	70 ± 6
30 °C	77 ± 16	Multimodal	37 ± 4	65 ± 7
50 °C	76 ± 12	Multimodal	35 ± 4	65 ± 9
80 °C	55 ± 8	Multimodal	47 ± 7	84 ± 6
Freeze-thawed	132 ± 3	0.38 ± 0.07**	139 ± 28	75 ± 13
Vortex	71 ± 7	Multimodal	49 ± 5	77 ± 10

^**based on 5 out of 6 measurements, as one was regarded as “multimodal” and did not result in a numerical PDI. The main peak of “freeze-thawed” was included into the larger bin as defined in Materials and Methods.