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. 2022 Nov 21;17(11):e0277606. doi: 10.1371/journal.pone.0277606

Table 3. Patients who discontinued treatment with DTG+3TC.

Patient Time to ART change (weeks) Reason Basal VL (c/mL) w4 w12 w24 Final ART Last VL (c/mL)
1 - VFa 779 - - 409 DTG/3TC <50
2 1 M184Vb 1,875 <50 - - DRV/c/TAF/FTC <50
3 2 CNS AE 142 - - - RPV+TDF/FTC <50
4 6 M184Vc 29,300 <50 - - DTG/RPV <50
5 16 CNS AE 219 - <50 - DRV/c/TAF/FTC LTFU
6 20 CNS AE 1,696 <50 <50 - RPV/TAF/FTC <50

ART: Antiretroviral treatment; VL: viral load; CNS AE: Central nervous system adverse event; VF: virological failure; LTFU: lost to follow-up.

aVF according to physician’s criteria (only one VL ≥ 200 copies/mL but the patient stopped treatment).

bThe participant had HIV-1 RNA 1,875 c/mL at baseline, switched to DRV/c/TAF/FTC on Day 8; <50 copies/mL on Day 59.

cThe participant had HIV-1 RNA 29,300 c/mL at baseline, <50 copies/mL on Day 43, switched to DTG+DRV/c on Day 43; switched to DTG/RPV afterwards.