Table 3. Patients who discontinued treatment with DTG+3TC.
Patient | Time to ART change (weeks) | Reason | Basal VL (c/mL) | w4 | w12 | w24 | Final ART | Last VL (c/mL) |
---|---|---|---|---|---|---|---|---|
1 | - | VFa | 779 | - | - | 409 | DTG/3TC | <50 |
2 | 1 | M184Vb | 1,875 | <50 | - | - | DRV/c/TAF/FTC | <50 |
3 | 2 | CNS AE | 142 | - | - | - | RPV+TDF/FTC | <50 |
4 | 6 | M184Vc | 29,300 | <50 | - | - | DTG/RPV | <50 |
5 | 16 | CNS AE | 219 | - | <50 | - | DRV/c/TAF/FTC | LTFU |
6 | 20 | CNS AE | 1,696 | <50 | <50 | - | RPV/TAF/FTC | <50 |
ART: Antiretroviral treatment; VL: viral load; CNS AE: Central nervous system adverse event; VF: virological failure; LTFU: lost to follow-up.
aVF according to physician’s criteria (only one VL ≥ 200 copies/mL but the patient stopped treatment).
bThe participant had HIV-1 RNA 1,875 c/mL at baseline, switched to DRV/c/TAF/FTC on Day 8; <50 copies/mL on Day 59.
cThe participant had HIV-1 RNA 29,300 c/mL at baseline, <50 copies/mL on Day 43, switched to DTG+DRV/c on Day 43; switched to DTG/RPV afterwards.