Figure 5.

The expression of inflammasome-related factors is elevated in mC26 but not in mHCT116 tumor mice. Expression of NLRP3 (A), IL-1β (B), and IL-18 mRNA (C) was analyzed by qPCR. D–F: Pearson product-moment correlations between each factor and muscle mass, respectively. Data are expressed as fold change from controls ± SD. A two-way ANOVA followed by a Tukey’s multiple comparisons test was performed for all direct comparisons between groups. Significant difference from control: *P ≤ 0.05, **P < 0.01, and ***P < 0.001; xenograft vs. metastasis: #P < 0.05, ##P < 0.01, and ###P < 0.001.