Figure 2.
Ex vivo resistance artery endothelial function does not differ with estrous cycle phase. Endothelium-dependent dilation to acetylcholine (ACh) in the presence and absence of nitric oxide synthase inhibitor Nω-nitro-l-arginine methyl ester (l-NAME) in the posterior cerebral artery (PCA; A) and mesenteric artery (B) from mice in proestrus, estrus, or diestrus. Endothelium-dependent dilation to insulin in PCA (C) and mesenteric artery (D) and endothelium-independent dilation to sodium nitroprusside in PCA (E) and mesenteric artery (F) from mice in proestrus, estrus, or diestrus. Repeated-measure ANOVA showed no differences were found between groups. n = 7–9/group. Data are means ± SD.